針對不同表面處理之鈦合金骨螺絲作生物親和性的評估

外文標題: 
Evaluation of Biocompatibility on Various Surface-Processed Titanium Screws: Animal Model
校院系所: 
國立成功大學 醫學工程研究所碩博士班
指導教授: 
張冠諒
主題類別: 
摘要: 

 本研究目的在於評估不同表面處理之鈦合金骨螺絲的生物親和性。植入物金屬表面除了施予多孔性處理外,亦在金屬表面披覆一層鈣磷酸鹽(calcium phosphate),或是電化學反應的發色處理,使金屬表面產生一層可以防腐蝕之氧化物。評估的方法則採用動物實驗,除了以掃描式電子顯微鏡(SEM)觀察植入物與組織間界面的情形外,亦使用光學顯微鏡(OM)觀察植入物周圍的組織形態。   結果顯示,除了硫酸發色處理之外,其它處理方式之植入物表面在12週或24週就可以達到骨整合(osseointegration),但鍵結之強度有待進一步作力學測試才可知曉。由SEM和OM觀察證實披覆鈣磷酸鹽之植入物具有骨傳導的能力,磷酸發色處理也可以達到同樣的效果。此外,從植入物表面周圍組織內之鈦元素偵測與組織學觀察比較結果,推論硫酸發色處理可以有效增加鈦合金表面之抗蝕性,但生物活性變差,較不具生物親和性。

外文摘要: 

 The purpose of this study was to evaluate the biocompatibilities of nine different surface-processed titanium screws. The types of surface processing included porous, calcium phosphate coating, porous + calcium phosphate coating, and coloring treatment of acid liquids. These implants were inserted into the proximal tibia epiphysis of rabbits and were examined after 12 and 24 weeks with optical microscope (OM) and scanning electron microscope (SEM) to observe the histological morphology and bonding condition between the implant and tissue.    Osseointegration was achieved at 12th and 24th week in all cases except coloring treatment of sulfuric acid. Without mechanical testing, however, interfacial shear strengths were not determined in the study. SEM and OM observations demonstrated calcium phosphate coating implants had the capability of osteoconduction, the same trend was found in coloring treatment of phosphoric acid. In addition to these phenomena, coloring treatment of sulfuric acid could promote resistance of corrosion on the titanium surface but relatively decrease the bioactivity, that is, lower biocompatibility.