沙門氏菌(Salmonella)感染目前仍然是世界上人類最主要的藉由食物來源的人畜共通傳染病病原，然而環境中的其他來源的機會仍可偶然的使人類感染沙門氏菌，而近年來有越來越多人飼養犬隻，犬隻也慢慢的由室外走入室內，與人類的生活有緊密的接觸。在臺灣地區，此菌過去曾有從犬隻分離到的紀錄，因此為了探討臺灣中部地區犬隻沙門氏菌感染的情形，本研究於2005年11月至2007年3月針對中部地區5個縣市的收容所犬隻及家犬進行調查，共採集樣本 1091個樣本，分離出168株沙門氏菌，收容所犬隻之總分離率為15.98％(160/1001)，各地區收容所的分離率分別為:苗栗縣2.44％(1 /41)，臺中縣15.53％(75/483)，臺中市12.63％(38/301)，彰化縣28％(35/125)，南投縣21.57％（11 /51）；此外，在家犬部分分離率為7.14％(8/108)。血清群部分以B(serogroup B)佔最多，為30.36％(51/168)，其次為C群28.57％(48/168)，E群22.02％(37/168)及D群16.67％(28 /168)。血清型以Salmonella Newport(16.67％)、Salmonella Enteritidis(10.30％)及Salmonella Senftenberg(4.17％)為主。在抗藥性方面，99.41％(167/168)的分離株對一種或一種以上的抗菌劑有抗藥性，單一抗菌劑抗藥性比例最高為Colistin(98.81％)，次為Tetracycline(38.1％)及 Nalidixic acid（27.98％）；此外，針對動物醫院使用抗菌劑的問卷調查結果顯示，以Cephalexin(18.5％)、 Gentamicin(13.8％)、Tetracycline(8.3％)及Ampicillin(8.3％)為最常使用的抗菌劑，顯示犬隻抗藥性的產生不全然是由動物醫院所致，可能還有其他的途徑造成犬隻感染具抗藥性的沙門氏菌。
Salmonella spp infection is an most important zoonosis worldwide by contamination of food. However, the salmonellae infect to human that the chance of other sources in the environment. In recent years, the dog which are closely related with human living and the Salmonella spp. were isolated form dog in Taiwan previously, so the aim of this study is to investigate the current status of the Salmonella infection in household and stray dogs in central Taiwan. In this study, samples were taken during the period November 2005 to March 2007. Rectal swabs from stray dogs were collected at five municipal animal shelters located in central Taiwan. For the household dogs, swabs were collected form veterinary establishments in Taichung city and county. Of total of 1001 dogs sampled, 168 Salmonella spp. were isolated, 15.98％（160/1001） were positive for Salmonella spp. of stray dogs：Miaoli county 2.44％（1/41）, Taichung county 15.53％（75/483）, Taichung city 12.63％（38/301）, Changhua county 28％（35/125） and Nantou county 21.57％（11/51）. Additionally, 7.14％（8/108） of household dogs were positive for salmonellae. The most frequently isolated serotypes were serogroup B（30.36％）, secondly was 28.57% of C group, 22.02% of E group, and 16.67% of D group. Salmonella Newport was the most prevalent serotype(16.67%), followed by Salmonella Enteritids (10.30%), and Salmonella Senftenberg (4.17%). The susceptibility of Salmonella isolates to fourteen antimicrobials, 99.41% (167/168) were resistant to one or more antimicrobial agents. Regardless of source, antimicrobial resistance was highest to Colistin（98.81％）, secondly was 28.57% of Tetracycline, and 27.98％ of Nalidixic acid. The result of questionnaire survey, Cephalexin（18.5％）, Gentamicin（13.8％）, Tetracycline（8.3％）, and Ampicillin（8.3％） was used usually in veterinary clinics, it was significant that Salmonella isolates exhibited resistance to antimicrobial agents in this study not only form animal hospital, it would cause by other ways.